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Umbilical Cord Blood to Treat Patients With Acute Myeloid Leukemia TreatmentBY: Ritu Choudhary | Category: Leukemia | Submitted: 2010-10-10 18:28:12
Stem cells can be made from umbilical cord blood. Acute myeloid leukemia (AML) occurs mostly in the elderly. Every year about thousands of people across the world suffer from leukemia. AML has been observed to be very common in people above the age of fifty five and their treatment using chemotherapy and radiotherapy is the last resort. But treatment of leukemia by vaccination is a god's gift for such patients. Cultured stem cells have power to curb the recurrence of cancer of patients who has already been successfully treated with cancer.
Leukemia is often returned
With chemotherapy, sometimes followed by a stem cell transplant, doctors try to destroy the proliferating white blood cells and thus to cure leukemia. In many cases this seems initially to be working well. But older patients are usually not candidates for a stem cell leukemia, and with them the often aggressive. The majority of the over-sixties, the disease therefore returned within three years and leads to death. Better treatment is therefore urgently needed, find the UMC, which is therefore a potential treatment using cord blood has been addressed.
Chemotherapy is not enough
Currently Leukemia patients first treated with chemotherapy for invasive white blood cells to eradicate. Most of the time there are some tumor cells behind, which then quickly multiply. After the chemotherapy is therefore actually still be handed a further blow, so that the latter tumor cells disappear. NK cells seem ideal candidates to pull it off. "
Stem cells from umbilical cord
Natural Killer Cells can also gain from donor blood, thus experiments yielded good results in patients with acute myeloid leukemia (AML). It is also very difficult to estimate adequately the dosage of killer cells from donor blood. Therefore follows the Laboratory of Hematology, in close cooperation with the firm Glycostem Therapeutics. They use stem cells from the umbilical cord and cultures through a special procedure for killer cells.
The cultured killer cells eliminate damaged, infected and abnormal cells and leave healthy cells alone. If the experiment is successful, the researched killer cells committed to other applications such as regenerative medicine
A team of researchers has managed to produce a personalized leukemia vaccine that helps in the immunization of the patients. This is a first in the development of cancer vaccines. The phase 1 / 2 clinical study was performed on adult patients with acute myeloid leukemia (AML) who have received chemotherapy but had a high risk of relapse. Acute myeloid leukemia (AML) in adults is an aggressive blood cancer which mainly affects older people over 60. Although the disease in most patients can be brought under control by chemotherapy, but relapse in them (relatively quickly) due to residual, albeit are often not numerous. The examined cell vaccine is custom made for the patient, ie based on the immune cells of the patient. The success, according to the researchers attributed to their choice of a powerful immune stimulant ingredient, derived from a component of cancer cells in combination with powerful immune cells. For the analysis, a team has worked very closely with the teams from Japan, United Kingdom and of Netherlands. The researchers have tested the vaccine but are currently only in small pilot studies in patients with other types of cancers such as multiple melanoma and breast cancer. The results were published recently in the renowned journal Proceedings of the National Academy of Sciences of the USA. This is a first in the field of development of cancer vaccines. It is an ideal starting point for a larger phase 2 study with a larger group of AML patients getting benefits forms such form of vaccinations.
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