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Research Work in CervicalBY: Ritu Choudhary | Category: Cancer Research and News | Submitted: 2010-08-08 10:05:17
Monitor, understand, treat cervical cancer The Pasteur Institute has several teams mobilized against cancer of the cervix, due to certain types of HPV and the second most common cancer in women worldwide. A cancer under close watch Following the recent marketing of the first preventive vaccine against cancer of the cervix, the Ministry of Health has created and placed at the end of 2008 the Pasteur Institute on the National Reference Center (NRC) for HPV human (HPV). The NRC's mission is to monitor the distribution of HPV in the European population and to track the possible emergence of new genotypes or variants of viruses in vaccines. More than forty types of HPV may infect the genital mucosa. The National Reference Centre for Human Papillomavirus (HPV NRC) mission is to develop a network of virology laboratories to monitor the distribution of HPV in women vaccinated and unvaccinated. After the recent marketing of the first preventive vaccine against cancer of the cervix, these tests should help track the possible emergence of new genotypes or variants of viruses in vaccines. Epidemiological studies in women unvaccinated or immuno-compromised (infected with HIV or grafted, for example) must also be used to estimate the prevalence and nature of HPV present in the genital area. The NRC will HPV expert missions, monitoring, alerting the authorities, training and technical assistance to laboratories. He is responsible for assessing the performance of different diagnostic tests would come on the market. It will develop new techniques for genotyping for the diagnosis of virus and antibody assays for the monitoring of vaccinated persons. This work will provide useful data to the Institute of Health for evaluation of vaccination policy. They will also identify the genotypes to be included in the second generation vaccines against papillomavirus. The CNR HPV is under the joint responsibility of Dr. Michel Favre, head of the Genetics Unit, Human Papillomavirus and Cancer at the Pasteur Institute and Dr. Isabelle Heard, hospital practitioner at the Hospital de la Pitie-Salpetriere . Cancer of the cervix in the world is the second most common cancer in women and thefirst e in developed countries. It was originally 250 000-300 000 deaths per year. In France, there are about 3,000 cases annually, and over 1,000 deaths. Cancer of the cervix is the first cancer recognized as 100% due to a viral infection. Papillomaviruses HPV 16 and 18 are responsible for more than 70% of cases. Towards a therapeutic vaccine against cancer of the cervix Unlike the previously proposed vaccine on the market, this candidate vaccine could act while the patient is already infected. The principle of this vaccination is to stimulate the immune system of patients to bring it to destroy cancer cells already infected. They are recognizable because they express the viral protein E7, which plays the role of signal recognition by the immune system. The researchers designed the vaccine for cervical cancer which looks like very effective. Candidate as a small missile with three stages: first, the head researcher, is designed to identify dendritic cells, the most effective to induce T-cell response white blood cells, key players in the immune system . The second floor carries the third, the E7 protein through the membrane of dendritic cells. Once inside the cell, the E7 protein is supported by the cellular machinery for presentation to T-cells and initiate immune response inside cancer effected organ. This candidate vaccine is directed against both HPV 16 and HPV-18: it would be effective against more than 70% of cancers of the cervix. A clinical trial in humans is currently being prepared by the company BT Pharma, if this trial is successful it will create a strong lead towards cervical cancer treatment. Article Source: http://www.cancer-surgery.com/ About Author / Additional Info: I am not a cancer doctor. Always consult your doctor before taking any action or conclusion regarding your medical condition. Comments on this article: (0 comments so far)
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