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Mesothelioma is a Dangerous Disease Which Has Taken Several LifeBY: Ritu Choudhary | Category: Other | Submitted: 2010-08-01 20:37:24
It is a benign or malignant, derived from serous tissues (pleura, peritoneum, pericardium). The pleural mesothelioma is a primary cancer, that is to say that it develops at the expense of the pleura without metastasis of another cancer. In 70-80% of cases, this cancer is related to exposure to asbestos may have occurred 30-40 years ago. We can expect an increase of this disease until 2020 because of asbestos imports increased until 1980. Currently in 1996, 900 new cases of mesothelioma are reported each year in Europe. This cancer is characterized by pleurisy bleeding, recurrence and intermittent pain, but sometimes it may be only a simple ordinary nonspecific pleural effusion. The type of asbestos affects the prevalence and incidence of mesothelioma. The amphiboles are the most carcinogenic (crocidolite, amosite, actinolite). Chrysotile is much less carcinogenic. Note that only the fibers are inhaled hazardous fibers are not ingested (mucus tract put them out of harm's way). The fibers are the most dangerous fibers more than 5 to 8 microns in length and diameter less than 1.5 microns. The bio-permanence of these fibers, especially amphiboles is very long. Once in the lungs, asbestos fibers reach the parietal pleura, either directly or via the lymphatic system and are concentrated in specific lymphatic structures that are like milky spots of lymphatic capillaries. Symptoms of Mesothelioma: The average age of the disease is 60 years, and this disease in more common in men. The sign of onset is most often pleurisy seems banal. However, heaviness and pain are frequently symptoms of Mesothelioma. In an exposed area it is therefore necessary before a table commonplace to think of a mesothelioma and implement additional tests needed to reach the diagnosis. The general condition is initially well preserved, later it may show fatigue, anorexia, weight loss may appear. Initially, the pleurisy is often minimal, clear liquid bloodless reaching the mediastinum is much later. The diagnosis is facilitated by thoracoscopy, that is to say by the introduction of a trocar equipped with an optical system in the pleural cavity. The scanner will be more useful to recognize the achievement of the mediastinal pleura. Thoracoscopy allows highlighting the nodules ranging from a few millimeters to 1 cm in diameter. These little buds are yellowish-white, slightly vascularized, translucent, sessile or pedunculated (see these terms) in grapes. Thoracoscopy allows the taking biopsy (see biopsy) of the nodules, thereby affirming the diagnosis. Thoracoscopy is the key to follow the evolution of the disease and its possible extension. Note that the diagnosis can be difficult at the beginning of evolution but nevertheless essential to quickly ask because it allows early treatment. However, it seems that the determination of serum osteopontin is a glycoprotein, allow an early diagnosis of the disease. The level of osteopontin is especially wil be high depending on high exposure to asbestosby the patient. The detection of mesothelioma stage-1 may be suspected if the cutoff of osteopontin rate of 62.4 nanograms per milliliter. The development is to fear the invasion of the mediastinal or visceral pleura, and mediastinum. Treatment of Mesothelioma Treatment of Mesothelioma is dependent on the stage of discovery of the disease. The care team may adopt different protocols, for example with early treatment by chemotherapy and immunotherapy endopleural by interleukin 2 (IL2) and interferon gamma (IFN gamma), seems the most useful. Sometimes the treatment of Mesothelioma is followed by surgery and radiation targeted components tangential to the lung-pleural. It seems that a new molecule which is an antifolate (pemetrexed) in combination with cisplatin would improve the prognosis improved, in particular, the quality of life: increased lung vital capacity, decreased dyspnea, and pain. Article Source: http://www.cancer-surgery.com/ About Author / Additional Info: I am not a cancer doctor. Always consult your doctor before taking any action or conclusion regarding your medical condition. Comments on this article: (0 comments so far)
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