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Liver Cirrhosis is the Major Cause of Liver CancerBY: Ritu Choudhary | Category: Liver Cancer | Submitted: 2010-07-18 19:27:53
The liver is a large organ located in the upper right abdomen and under the ribs. It is involved in many activities. It produces essential blood clotting factor, which helps in preventing bleeding. It produces bile which is needed to digest fat. There are two types of liver cancer- The primary liver cancer or hepatocellular carcinoma, which develops from cells of the liver. The secondary cancer, when the liver is affected by cancer cells from another location also referred as metastasis. Most of the hepatocellular carcinoma develops due to cirrhosis of liver. The cirrhosis is the result of a slow transformation of the liver in a hard organ. The cirrhotic liver is gradually formed scar tissue that is gradually replacing the cells necessary for its operation. Cirrhosis has high risk of developing nodules that can become cancerous. The causes of cirrhosis are not limited to only excessive consumption alcohol but also dependent on other factor. Cirrhosis apart from drinking may occur due to viral hepatitis, when they become chronic. Besides alcohol and viral hepatitis, cirrhosis may also be due to genetic diseases, impairment of the immune system, a metabolic disease. Among all cancers, liver cancer is considered as very serious, as it is primarily diagnosed in very late stage. Indeed, liver caner generally remains silent for long: the changes are often invisible and therefore difficult to detect, so for many years, cirrhosis can exist without symptoms or with symptoms that has no characteristic. Thus, it is common as cirrhosis and cancer are identified at the same time. The following symptoms should lead to consult a doctor even though their causes may be multiple and unrelated cancer like pain in the liver, fever, impaired general condition, jaundice, etc. When identified, the liver cancer often consists of multiple small tumors increasing complexity of the therapeutic management. The treatment of HCC is based on strategies that take into account the characteristics i.e. number and size, development of the tumor and severity of cirrhosis. The best cure is liver transplantation, whatever the cause of cirrhosis. This is a major surgery. The disease causing cirrhosis can be cured or at least stabilized and, by quitting alcoholism and smoking cessation for several months. It is still reserved for patients aged less than 65 years old with a cancer rather limited and relatively aggressive. Indeed, the shortage of grafts involves waiting an average of 6 to 12 months, requiring "treatment withdrawal" of cancer. The transplantation requires, eventually, a permanent monitoring and treatment to ensure tolerance graft and to avoid rejection. Alternatively, excision is usually indicated for people with cancer without cirrhosis or with well-compensated cirrhosis. It remains rather reserved for patients with single tumor and maintaining good liver function because of tumor recurrence in liver cirrhosis is common. Alternative to resection, percutaneous tumor destruction may be affected by radiofrequency. However, in 75% of cases, the use of a cure is impossible. The chemo-embolization treatment that involves 20% of patients which involves injection into the hepatic artery, chemotherapy and balls that will clog up the artery and prevent cancerous nodule vasculature. Currently a new therapeutic approach is being tested: the anti-angiogenic agents designed to destroy the blood vessels supplying the tumor or preventing their development. The prevention is to avoid the development of liver diseases. Know and avoid the risk of transmission, immunization against hepatitis B, etc. provide protection from viral hepatitis. The elimination of other risk factors especially alcohol or obesity, screening for hepatitis C are as many ways to act quickly in case of illness and avoid complications support the development of liver cancer. In cirrhotic patients, the prevention involves reducing risk factors and regular screening: every 4-6 months by ultrasonography combined with a blood test, measurement of alpha-fetoprotein. However, liver cancer remains difficult to detect early. Article Source: http://www.cancer-surgery.com/ About Author / Additional Info: I am not a cancer doctor. Always consult your doctor before taking any action or conclusion regarding your medical condition. Comments on this article: (0 comments so far)
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