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How Obesity is Related to Pancreatic Cancer?BY: Ritu Choudhary | Category: Pancreatic Cancer | Submitted: 2010-06-27 08:02:09
The cancer of the pancreas is known to have a poor survival rate. According to new findings, the obesity increase the risk of pancreatic cancer but this risk could be reduced even moderate physical activity. This link between obesity and pancreatic cancer has been examined by researchers at Harvard University. Individuals whose body mass index (BMI) greater than or equal to 30 were more likely to develop pancreatic cancer. Recently, a study of patients who underwent pancreatic surgery showed that the outcome was even worse for those with a body mass index (BMI) over 35 - the duration of survival is lower, the recurrence and release are more likely to occur. We know that obesity increases the risk of various cancers. Previous research has shown that there was an increase in the prevalence of pancreatic cancer in obese people and obesity is also correlated with lower chances of survival. The reason why obesity is a risk factor is unclear and further studies may identify biomarkers that can be monitored. As the number of obese people is increasing, it is likely that the impact of this risk factor affects the survival rate of pancreatic cancer in the future. A team from the University of Texas, MDAnderson Cancer Center for studied 285 patients who underwent surgery for pancreatic cancer between 1999 and 2006. The data concerning the surgery, the BMI of patients and outcome were recorded in the databases and medical records. A total of 53% patients were dead after 16 months of surveillance. Patients with BMIs exceeding 35 had a median survival of 13 months against 27 months for those BMI was below 23 - in other words, the two extreme categories of BMI were compared. At the last follow-up examination, 75% of those with a BMI above 35 had died, against 52% of those whose BMI was at or below 35. The researchers also found a subgroup of patients with a BMI over 35, who were 12 times more likely to have lymph node metastasis than those with a BMI below 35. In sum, the rate of overall survival and disease-free lowered for obese patients and the risk of recurrence and death after surgery were almost double compared to patients who were not obese. The recurrence of cancer is 95% among patients with a BMI over 35, against 61% for all others. These results extend previous observations regarding the BMI and pancreatic cancer, for those going through surgery. It seems that obesity is a factor that influences tumor biology of pancreatic cancer. The further research will identify biomarkers associated with risk, which can be studied and provide information on the prognosis of some obese patients with cancer of the pancreas. In the meantime, here is another good reason to pay attention to his weight. Moderate exercise appears to lower the risk of cancer of the pancreas. According to the researchers, 1.5 hours walk or more per week reduces risk of pancreatic cancer in men and women. Physical activity does not alter the risk of pancreatic cancer when the BMI is below 25, i.e. when individuals are not overweight. In contrast, total physical activity was inversely associated with risk of pancreatic cancer is when the BMI exceeds 25. According to researchers the association between physical activity and risk of pancreatic cancer was greater among obese subjects who were more likely to have abnormal glucose levels and that could benefit from an improved response to glucose. They believe that these data suggest that insulin resistance and hyperinsulinemia play a role in the development of pancreatic cancer. Reduce the risk of pancreatic cancer by changing diet and promoting physical activity and smoking cessation. Article Source: http://www.cancer-surgery.com/ About Author / Additional Info: I am not a cancer doctor. Always consult your doctor before taking any action or conclusion regarding your medical condition. Comments on this article: (0 comments so far)
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