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Correlation Between Breast Cancer Hormone Replacement TherapyBY: Ritu Choudhary | Category: Breast Cancer | Submitted: 2010-10-23 20:35:44
Correlation between breast cancer hormone replacement therapy
The most recent studies have shown that increased risk of breast cancer is linked to a long-term treatment, in addition, the type of estrogen and progesterone as well as how to take Treatment (route) also plays an important role. It is therefore important that hormone therapy is tailored to the individual woman. The hormone replacement therapy slightly increases the baseline risk as well as other risk factors such as family history of breast cancer, the fact of not having children or late pregnancy.
The majority of breast cancers are hormone-dependent, meaning that cancer cells carry receptors capable of binding the female hormones, which will accelerate the proliferation of cells and thus the development of cancer. It is for this reason that when one was oneself suffering from breast cancer, it is forbidden to take hormones by systematic (that is, a form of treatment to resorption hormones and their dissemination through the bloodstream throughout the body).
Since several studies have highlighted the link between HRT and increased risk of breast cancer, many women are concerned, sometimes to abandon their treatment. But be aware that all hormonal treatments have different effects on risk of breast cancer. It is a question of association between estrogen and progesterone. Estrogen alone did not increase significantly this risk. In addition, all progesterone are not equal. Studies have shown that the incidence of breast cancer is more dependent on the type of progesterone. Finally, another extremely important factor is the duration of hormonal treatment. "If you take hormones for less than 5 years, the risk of breast cancer is identical to that of the general population. But beyond 5 years, the risk increases, peaking especially after 10 years. If patients do not feel well, they have hot flashes, and they have tried herbal remedies, products counter in pharmacies, etc. then offer a short-term hormone therapy. It is taken for 4 years, then stopped, and then see the results.
Not only the risk depends on the chosen treatment and its duration, but the effect of treatment on this risk is small. 12.5% of the female population will have breast cancer in her lifetime. When you take long-term hormone therapy, the risk increase from 0.5 to 1%. Instead of having a risk of 12.5%, there is a risk of 13% or 13.5%. There are women who stop HRT for fear of cancer. But these women are forgetting one thing that stopping the treatment, their risk of breast cancer does not go down to zero, It is only down 13% or 13.5% to 12.5%. So they earn a tiny difference. So yes, hormones influence the risk of breast cancer, but only a little. What is important is to monitor, move mammograms, mammotests, etc.
Many women have heard of slightly increased risk of breast cancer associated with HRT, very few know that other factors come into play. With breast cancer, thrombosis is another major risk of hormone treatment. "That's why at a certain age, it is important to stop the pill because they are synthetic hormones that increase the risk of thrombosis more than natural hormones. It is therefore appropriate to give cons-hormonal treatment to a woman who has already made a pulmonary embolism or deep vein thrombosis. If they can not do anything compared to some of them (heredity, age, etc.), they may act by cons on other, observing a healthy lifestyle. First weight: having a BMI above 31 increases the risk by 50% compared to the general population. So we can reduce this risk by losing a few pounds. Tobacco and alcohol: smoking, even passive, increases the risk of breast cancer, as well as alcohol, whatever its origin beyond three glasses per day. Physical inactivity: sport (walking, swimming, etc.) per week greatly reduces the risk of breast cancer.
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